声触诊组织定量技术在甲状腺弥漫性病变中的应用价值

Evaluation the application value of virtual touch for diffuse thyroid diseases

99例甲状腺弥漫性病变患者分为两组:Graves病(GD)组45例;桥本甲状腺炎(HT)组54例。另选取甲状腺功能及超声图像正常者64例进行对照比较,对病变组及正常对照组甲状腺组织行声触诊组织定量(VTQ)技术检查,记录各甲状腺组织的剪切波传播速度(SWV)。比较3组甲状腺组织的SWV。GD组、正常对照组、HT组SWV值依次增大,差异有统计学意义(P<0.05)。对病变组绘制受试者工作特征曲线(ROC),当SWV≥2.20 m/s时,诊断HT的敏感性和特异性分别为90.7%和84.4%,阳性似然比和阴性似然比分别为5.81和0.11,约登指数为75.1%。结果表明VTQ技术在常规超声的基础上能对甲状腺组织的硬度进行定量测算,有助于临床鉴别GD及HT。

A total of 99 patients with diffuse thyroid diseases were divided into two groups：one group included 45 cases with Grave＇s Disease（GD）,the other group included 54 cases with Hashimoto＇s thyroiditis（HT）.Virtual touch tissue quantification（VTQ） technique was used to measure the shear wave velocities （SMV） of thyroid lobes of the two groups,and the control group included 64 people who had normal thyroid function and ultrasonoscopy.The results of the three groups were compared.The value of SMV among the GD group,the control group and the HT group,in turn,increased,with statistically significant differences （P ＜ 0.05）.Receiver operating characteristic （ROC） curve was drawn to assess the diagnostic accuracy.The sensitivity and specificity of SMV （cut-off value =2.20 m/s） in diagnosing GD and HT was 90.7％ and 84.4％ respectively.The positive likelihood ratio（LR ＋） and negative likelihood ratio（LR-） was 5.81 and 0.11 respectively.The Youden index was 75.1％.In conclusion,VTQ technology on the basis of conventional doppler ultrasound can assess the thyroid tissue quantitatively,and help clinical identification of GD and HT.