不同品系小鼠在禁食和(或)禁水情况下血糖变化特点的比较分析

Comparative analysis of blood glucose changes of different strains of mice under food and/or water deprivation

目的比较不同品系小鼠在禁食和(或)禁水情况下的血糖变化特点,为研究不同品系动物血糖代谢水平的差异提供参考依据。方法选择C57BL/6J小鼠、BALB/c小鼠、ICR小鼠作为研究对象,进行禁食和(或)禁水胁迫压力测试,分为正常进食进水组、禁食不禁水组、禁水不禁食组和禁食禁水组共4组,测定胁迫压力后12 h内血糖的变化。结果与结论 3种品系小鼠血糖变化趋势有所差异,其中C57BL/6J小鼠整体血糖浓度高于BALB/c和ICR小鼠,BALB/c小鼠的血糖变化相对较为平稳,而ICR小鼠的血糖变化幅度最大。结果提示在进行血糖代谢相关研究中,需同时考虑不同品系动物血糖代谢能力差异,从而选择合适的动物进行研究并对数据进行合理分析和解释。

Objective To provide reference on the difference in blood glucose metabolism between different mouse strains by comparing blood glucose changes under food and/or water deprivation.Methods C57 BL/6J mice,BALB/c mice,and ICR mice used in this study were divided into four groups：control group,food deprivation group,water deprivation group and food water deprivation group.Their blood glucose was measured within 12 hours under various stresses.Results and Conclusion There are different blood glucose regulation patterns in different mice strains.The blood glucose level of C57 BL/6J mice is usually higher than that of the BALB/c and ICR mice,while the of blood glucose level BALB/c mice stays relatively stable,and the ICR mice have the widest range of blood glucose levels upon these stresses.According to our data,the difference in blood glucose metabolism between different mouse strains should be taken into consideration in blood glucose related studies for proper interpretation and design of experiments.