鼻腔未分化癌2例

Sinonasal undifferentiated carcinoma:2 cases report

1病例报告 例1男,56岁。因左侧鼻腔反复出血1月余于2011年8月20日入院。1个月前患者突发不明原因的左侧鼻腔流血后反复发作,呈鲜红色,可以自行停止,伴轻度鼻塞。无头痛、头昏、溢泪,无嗅觉下降、面部麻木。门诊检查见左侧鼻腔新生物,给予活检,病理提示为恶性肿瘤,细胞分化不明。为进一步治疗入我院。专科检查：左侧鼻腔中段新生物,表面不平,触之易出血,根基位于下鼻甲中段;右侧鼻腔无异常,鼻中隔无偏曲,

Sinonasal undifferentiated carcinoma happens rarely,the clinical manifestations of the disease lacked specificity,with nasal obstruction and blood mainly in a unilateral nasal cavity.Two casas were reviewed,one case of tumor located in the middle of inferior turbinate;1in the bottom wall of the anterior nasal cavity.The tumor appeared dark red and unsmooth surface.Sinus CT scan showed occupying shadow and significant bone destruction.Complete resection of the lesion was performed.The pathology of neoplasm showed small-medium sized oval nuclei,high nucleus to cytoplasm ratio,and active mitosis.The pathological diagnosis was undifferentiated carcinoma.Comprehensive treatment of postoperative radiotherapy and chemotherapy were given,distant metastasis still happened.One survived in 2years of follow-up,1patient died in 18months.