USP24基因多态性与中国北方散发性帕金森病相关性

CORRELATION BETWEEN USP24 POLYMORPHISM AND SPORADIC PARKINSON'S DISEASE IN NORTHERN CHINA

目的探讨泛素-特异蛋白酶24(USP24)基因多态性与散发性帕金森病(PD)的相关性。方法采用病例-对照研究方法,应用聚合酶链反应-限制性片段长度多态性技术,对中国北方地区汉族人群207例散发性PD病人和218名健康对照者(对照组)的USP24基因rs487230多态性位点进行研究,并比较其在PD病人和正常对照人群中的频率分布。结果 PD组和对照组USP24基因rs487230的等位基因分布、各基因型频率差异均无显著(P>0.05)。结论中国北方汉族人群中USP24rs487230C>T基因多态性与PD发病不相关。

Objective To investigate the relationship between USP24 polymorphism and sporadic Parkinson＇s disease. Methods Genotyping USP24 polymorphism in 207 patients with Parkinson＇s diseas and 218 healthy controls was analyzed using polymerase chain reaction restriction fragment length polymorphism （PCR RFLP） technique. Results No significant differences in SNP rs487230 in USP24 gene were observed between the patients and the controls. Conclusion O[ Han population in northern part of China, the USP24 polymorphism is uncorrelated with the pathogenesy of Parkinson＇s disease.