AD与MCI病人情景记忆编码及提取加工变化

THE ABNORMAL PROCESS OF ENCODING AND RETRIEVING OF EPISODIC MEMORY IN PATIENTS WITH ALZHEIMER'S DISEASE AND MILD COGNITION IMPAIRMENT

目的观察阿尔茨海默病(AD)及轻度认知障碍(MCI)病人情景记忆(EM)编码和提取加工的变化。方法 AD组病人55例,MCI组病人86例,正常对照组(NC组)95例。应用E-prime软件进行情景记忆编码和提取测试,记录编码和提取成绩及反应时。结果 AD组和MCI组编码正确率均低于NC组,差异有显著性(F=22.3,q=2.9、6.6,P<0.05),且AD组低于MCI组,差异有显著性(q=3.9,P<0.05);AD组和MCI组提取正确率均低于NC组,差异有显著性(F=24.6,q=2.4、5.0,P<0.05),且AD组低于MCI组,差异有显著性(q=2.4,P<0.05);AD组和MCI组编码反应时较NC组明显延延长,差异均有显著性(F=23.1,q=3.5、6.8,P<0.05),且AD组较MCI组明显延长,差异有显著性(q=3.7,P<0.05);AD组和MCI组提取反应时较NC组明显延长,差异均有显著性(F=12.8,q=3.3、6.6,P<0.05),且AD组较MCI组明显延长,差异有显著性(q=3.3,P<0.05)。结论AD和MCI病人情景记忆编码和提取加工出现损伤,且AD病人较MCI病人损伤明显。

Objective To investigate the changes of encoding and retrieving of the episodic memory（EM）in patients with Alzheimer＇s disease（AD）and mild cognition impairment（MCI）. Methods This study consisted of 55 AD patients,86 MCI patients and 95 normal controls（NC）.Using E-prime software,episodic memory encoding and retrieving tests were done.Scores of encoding,retrieving and reaction time were recorded. Results The accuracy rate of encoding in AD and MCI was lower than that in NC（F=22.3;q=2.9,6.6;P〈0.05）,and that in AD was lower than MCI（q=3.9,P〈0.05）.Retrieval accuracy：that in both AD and MCI groups was lower than that in NC（F=24.6;q=2.4,5.0;P〈0.05）,and that in the AD was lower than the MCI,difference was statistically significant（q=2.4,P〈0.05）.The reaction time of encoding in groups AD and MCI was longer than that in group of NC（F=23.1;q=3.5,6.8;P〈0.05）,and group AD was longer than group MCI（q=3.7,P〈0.05）.Reaction time of retrieving in both groups AD and MCI were obviously extended compared with NC（F=12.8;q=3.3,6.6;P〈0.05）,and that in AD was longer than MCI（q=3.3,P〈0.05）. Conclusion Processing of episodic memory encoding and retrieval in patients with Alzheimer＇s disease and mild cognition impairment are damaged,the former are more obviously involved.