丙泊酚TCI全麻诱导在颅内动脉瘤介入治疗中的应用

Application of propofol TCI-induced general anesthesia in interventional treatment of intracranial aneurysm

目的：探讨颅内动脉瘤介入治疗中丙泊酚全麻诱导靶控注射与人工输注方式的临床价值。方法选取2011~2012年我院颅内动脉瘤介入治疗的患者60例，随机分为两组行不同方式的丙泊酚麻醉诱导，统计两组患者不同麻醉时间的血流动力学指标以及麻醉效果。结果两组患者麻醉诱导时间、苏醒时间无明显差异；相比对照组，观察组丙泊酚用量明显较高，麻醉效果明显较好，诱导期后血压下降明显较少，不良反应发生率明显较低。结论颅内动脉瘤介入治疗中丙泊酚靶控输注相比人工输注具有更好的麻醉效果，血液动力学指标变化较小，安全性更高，适合临床推广。

Objective To explore the clinical value of target controlled infusion-induced general anesthesia with propofol and manual infusion in interventional treatment of intracranial aneurysm. Methods 60 patients who received interventional treatment of intracranial aneurysm in our hospital from 2011 to 2012 were selected and randomly assigned to two groups which received two different ways of anesthesia induction with propofol. Hemodynamic parameters and anesthetic effects at different time of anesthesia in the two groups were collected. Results Anesthesia induction time and awakening time between the two groups were not significantly different;compared with the control group, the amount of propofol used in the observation group was significantly larger, and the anesthetic effect was obviously better. Fall of blood pressure after the induction was evidently minor and the incidence rate of adverse events was significantly lower. Conclusion In the interventional treatment of intracranial aneurysm, TCI with propofol has better anesthetic effect than manual infusion. It causes minor changes of hemodynamic parameters, which is a safer method and worthy of clinical promotion.