乳腺癌组织VEGF-A、COX-2的表达与预后生存分析

Expression and prognostic analysis of VEGE- A,COX- 2 in breast cancer tissue

目的:检测乳腺癌术后组织中VEGF-A、COX-2的表达,并进行随访,分析两者与乳腺癌患者预后的关系。方法:采用SP免疫组化法检测乳腺癌术后组织中VEGF-A、COX-2的表达,并采用Kaplan-meier法、Log-rank法和Cox比例风险模型将两者的表达与乳腺癌患者生存期进行统计分析。结果:乳腺癌术后组织VEGF-A阳性表达率明显高于乳腺良性组织(70.00%、44.11%),COX-2阳性表达率亦高于乳腺良性组织(66.67%、17.65%),同时COX-2阳性组患者的VEGF-A阳性率明显高于阴性组(80.00%、50.00%),且均有统计学意义(P<0.05);患者的临床分期、淋巴结转移状态、C-erbB-2、VEGF-A、COX-2与患者的预后有关。结论:多因素Cox回归分析显示乳腺癌组织VEGF-A、临床分期是乳腺癌患者预后的影响因素。

To study the expression of postoperative tissue VEGF - A,COX - 2,and analyze the rela-tionship with the prognosis of breast cancer. Methods：Postoperative tissue VEGF - A,COX - 2 were detected by SP immunohistochemical technique. Relation of VEGF - A,COX - 2 with breast cancer＇s survival was analyzed by Cox proportional hazards model,Kaplan - meier and Log - rank methods. Results：The positive expression rate of VEGF -A was higher in breast cancer than benign disease（70. 00% ,44. 11% ）,the positive expression rate of COX - 2 was higher in breast cancer than benign disease（66. 67% ,17. 65% ）,and the positive expression rate of VEGF - A higher in the group of COX - 2 positive（80% ,50% ）,all had the statistical significance（P ﹤ 0. 05）. Patient＇s prognosis had the relationship wih clinical stage,lymph node status,C - erbB - 2,VEGF - A and COX - 2. Conclusion：Cox multi-variate regression analysis showed that the VEGE - A of breast cancer＇s postoperative tissue,clinical stage are the prognostic factors in breast cancer.