结肠癌转移相关基因1与c-met在子宫内膜癌中的表达及其临床价值

The expression and significance of MACC1 and c- met protein in endometrial carcinoma

目的:探讨MACC1与c-met蛋白在子宫内膜癌中的表达及其临床意义。方法:应用免疫组织化学方法检测45例子宫内膜癌组织、38例增生子宫内膜组织、20例正常子宫内膜组织中MACC1与c-met蛋白的表达情况,分析两者在不同子宫内膜中的表达率及其与子宫内膜癌临床病理参数的关系,并分析两指标在子宫内膜癌组织中表达的相关性。结果:MACC1与c-met在子宫内膜癌组织中的阳性表达率显著高于增生子宫内膜组织、正常子宫内膜组织(P<0.05)。MACC1与c-met在子宫内膜癌组织中的表达与肌层浸润深度、手术病理分期、组织分化级别显著相关,而与年龄、肿瘤大小等无关。MACC1与c-met蛋白的表达呈正相关(P<0.05)。结论:MACC1与c-met在子宫内膜癌组织中表达增高,肌层浸润较深、手术病理分期越晚、组织分化程度较低者表达率更高,两者与肿瘤的发生、发展、转移关系密切。

To detect the expression of MACC1 and c - met protein in endometrial carcinoma and study its significance. Methods：Immunohistochemistry assay was used for the detection of MACC1 and c - met protein in 45 endometrial carcinoma cases,38 hyperplasia endometrium cases,20 normal endometrial cases. Results：The positive expression rate of MACC1 and c - met protein in endometrial carcinoma tissue were both significantly higher than those in hyperplasia endometrium tissue and normal endometrial tissue（P ﹤ 0. 05）. All of their expressions were relat-ed with myometrial invasion,surgical pathologic stage and tissue differentiation level（P ﹤ 0. 05）. While there were no significantly relationship with age and size of the tumor. In addition,the expression of MACC1 and c - met protein were positively correlated with them in endometrial carcinoma（P ﹤ 0. 05）. Conclusion：MACC1 and c - met were highly expressed in endometrial carcinoma. Infiltrating deeper at the grass - roots level,the later surgical pathologic stage,tissue differentiation degree lower expression rate higher,both closely related to occurrence,development,and metastasis of tumor.