异甘草酸镁在妇科恶性肿瘤术后辅助化疗时护肝作用研究

Hepatoprotective effect of magnesium isoglycyrrhizinate on hepatic injury induced by postoperative chemotherapy in gynecologic malignant cancer

目的:观察异甘草酸镁在妇科恶性肿瘤术后辅助化疗时的护肝作用。方法:将妇科恶性肿瘤术后首次化疗患者总计120例,随机分为2组,治疗组(60例)化疗首日开始每日予以异甘草酸镁注射液护肝,对照组(60例)予以门冬氨酸钾镁注射液护肝。观察比较化疗前后肝功能的变化。结果:治疗前查肝功能,治疗组与对照组的各检测指标无显著差异。2周治疗后,复查肝功能,治疗组各检测指标均显著低于对照组(P<0.05)。结论:异甘草酸镁能显著减轻妇科恶性肿瘤患者辅助化疗引起的肝功能损伤,降低化疗药物性肝损害的发生率。

To observe the hepatic - protection functions of magnesium isoglycyrrhizinate in the patients with gynecological malignant tumors on postoperative chemotherapy. Methods：A total of 120 patients with gynecologi-cal malignancies who accepted postoperative chemotherapy for the first time were divided into two groups. Treatment group（60 cases）received magnesium isoglycyrrhizinate for intravenous injection and control group（60 cases）was given potassium magnessium aspartape injection intravenously since the first day of chemotherapy. The changes of liver function of both groups were compared before and after the treatment. Results：Before treatment,liver function tests showed that there was no significant difference between the control group and treatment group. After two weeks＇ treat-ment,the tests showed that the figure of liver function tests of treatment group was obvious lower than that of control group（P ﹤ 0. 05）. Conclusion：Magnesium isoglycyrrhizinate is significantly effective on treating chemotherapy - re-lated liver lesion in the patients with gynecologic malignant tumor and reducing the incidence rate of chemotherapy -related liver lesion.