PEDF、CCR7和MMP9在食管癌中的研究进展

Advances in study on PEDF,CCR7 and MMP9 of esophageal carcinoma

色素上皮衍生因子(pigment epithelium-derived factor,PEDF)作为丝氨酸蛋白酶抑制剂超家族中的非抑制性成员,具有抗血管生成和抗肿瘤特性。趋化因子受体(CC chemokine receptor,CCR)7属趋化因子受体超家族,与肿瘤侵袭、淋巴结转移密切相关。基质金属蛋白酶(matrix metalloproteinase,MMP)9为MMP家族成员之一,通过基质降解和促血管生长参与肿瘤发生发展过程。本文就PEDF、CCR7和MMP9在食管癌的最新研究进展作一综述。

As a non - inhibited member of the serine protease inhibitor（serpin）superfamily,Pigment epithelium -derived factor（PEDF）has the antiangiogenic and antitumorigenic activities. CC chemokine receptor（CCR）7 be-longs to the chemokine receptor superfamily,and is closely related to tumour cell invasion and lymphatic metastasis. Matrix metalloproteinase（MMP）9 is a member of Matrix metalloproteinase family,and takes part in the generation and development of the tumor through degrading the matrix and stimulating the growth of blood vessels. This article re-viewed the latest advances in the study on PEDF,CCR7 and MMP9 in esophageal carcinoma.