鼠神经生长因子联合高压氧早期干预高危婴儿脑损伤疗效分析

Clinical effect of mouse nerve growth factor combined with high pressure oxygen on early intervention of brain damage in high-risk infants

目的观察鼠神经生长因子（NGF）和高压氧治疗高危婴儿脑损伤的疗效,探讨高危婴儿脑损伤的治疗方法。方法对2010年1月至2013年12月在该院产科出生及儿童保健门诊就诊的92例0～1岁脑损伤高危婴儿进行早期干预治疗。根据不同治疗方案分为对照组28例、NGF组21例、高压氧组19例、NGF联合高压氧组24例。对照组仅给予一般治疗;NGF组在对照组治疗基础上加用NGF,用量为20μg/d,肌内注射,连用10 d,停用20 d为一疗程,连用5个疗程;高压氧组在对照组基础上给予高压氧治疗,压力为30.3～50.5 kPa,吸氧60 min,每天1次,10次为一疗程,停用20 d后重复,5个疗程;NGF联合高压氧组在对照组治疗基础上给予NGF联合高压氧治疗,方法同上。比较各组临床治疗效果。结果 NGF组、高压氧组、NGF联合高压氧组有效率均高于对照组,NGF联合高压氧组有效率高于NGF组、高压氧组,差异均有统计学意义（P〈0.05或0.01）;NGF组与高压氧组有效率比较,差异无统计学意义（P〉0.05）。结论NGF与高压氧的联合使用对高危婴儿脑损伤可增加干预效果。

Objective To observe the effects of mouse nerve growth factors（NGF）and high pressure oxygen（HPO） on brain damage in high-risk infants, and investigate the therapeutic method of brain damage. Methods A total of 92 high-risk infants with brain damage during 0-1 years old,who were born in the Obstetrical Department or treated in Child Health Division in the hospital from January 2010 to December 2013,were treated with early intervention. According to the therapeutic schedule,all the infants were divided into control group（n=28）,NGF group（n=21）,HPO group（n=19） and combination group of NGF and HPO（n=24）. The control group only used general treatment;the NGF group was with intramuscular injection with 20 μg/d mouse NGF on the basis of the control group for continuous 10 d,discontinuation of 20 d was a period,and 5 periods were necessary;the HPO group was added with HPO for treatment,with the pressure of 30.3-50.5 kPa,oxygen inhalation of 60 min,once every day,and 10 times was a course of treatment,5 courses were repeated after discontinuation of 20 d;the combination group was added with NGF associated with HPO on the basis of general treatment,it was the same way as above. The clinical efficacy of the 4 groups were compared. Results The effective rate of NGF group,HPO group and combination group was higher than that of the control group,the effective rate of combination group was higher than that of the NGF group and HPO group,and the differences were statistically significant（P〈0.05 or 0.01）,but the difference of effective rate between NGF group and HPO group had no statistical significance（P〉0.05）. Conclusion The application of mouse NGF associated with HPO can improve the intervention efficacy of brain damage in high-risk infants.