住院患者感染鲍曼不动杆菌临床分布及耐药特点研究

CLINICAL DISTRIBUTION AND ANTIBIOTICS RESISITANCE CHARACTERISTIC OF Acinetobacter baumannii ISOLATED FROM HOSPITAL

目的研究医院住院患者鲍曼不动杆菌感染临床分布及其耐药特点,为指导临床抗菌药物合理应用提供科学依据。方法通过回顾性调查和病原学标本检验方法,对某中医院(TCM)住院患者感染鲍曼不动杆菌情况及其送检标本进行调查和分离鉴定。结果在调查期间从该中医院住院患者送检标本中,共检出鲍曼不动杆菌617株,其感染病人主要分布于神经外科、呼吸内科和重症监护室(ICU)。分离出鲍曼不动杆菌的标本主要来自病人呼吸道,构成比为82.82%;其次为分泌物和尿液标本。临床分离的鲍曼不动杆菌对常用抗菌药物的耐药率均较高,对亚胺培南及美罗培南的耐药率达到57.6%和67.5%。结论该中医院鲍曼不动杆菌感染病人主要分布于神经外科、呼吸内科和ICU,其对临床常用抗菌药物普遍耐药,根据药敏试验结果合理选择抗菌药物为主要防控措施。

Objective To investigate the clinical distribution and drug resistance characteristic of Acinetobacter Baumannii（ ABA） isolated from hospital of TCM,and to provide significant evidences for conducting clinical practice involved in ABA infection therapy. Methods Retrospective study was conducted to analyze the samples of the patients with ABA infection isolated from hospital of TCM. Results 617 strains of ABA were isolated from the samples of ABA infected patients in the hospital. ABA was mainly obtained from respire sputum（ 82. 82%）,secretions and urine related samples. The samples were largely from the department of Neurological Surgery,the department of Respiratory and ICU. The isolated ABA had high capacity of common antibiotic resistance. The drug resistance ratio to Imipenem and Meropenem were 57. 6% and67. 5% respectively. Conclusion The ABA infected patients are mainly located in the department of Neurological Surgery,the department of Respiratory and ICU,and are resistant to common antibiotics. Optional selection of antibiotics would be better for ABA infection related disease.