造血干细胞采集前后亲缘及非亲缘供者心理健康状态比较

Mental health status of relative donors versus unrelated donors before and after hematopoietic stem cell collection

背景:目前造血干细胞移植主要依靠在非血缘关系供者中寻找相合者。非亲缘造血干细胞捐献者的心理状态对于保证顺利完成移植,使受者得到有效治疗非常重要。目的:比较亲缘及非亲缘供者造血干细胞采集前后心理及生理健康状态。方法:分别在入院时,采集前(1 d),采集后(一两天),1个月后回访4个时间点对亲缘与非亲缘供者的心理状态(SCL-90症状自评量表评分)及一般生理指标(体温,呼吸,脉搏,血压)进行评估比较。结果与结论:在入院时,亲缘与非亲缘供者的心理健康水平差异无显著性意义(P>0.05);而在采集前、采集后,非亲缘供者的SCL-90总分、强迫、抑郁、焦虑、敌对、恐惧分值高于亲缘供者(P<0.05);1个月后回访,大多数分值差异无显著性意义(P>0.05)。非亲缘和亲缘供者的生理指标平稳,但在采集前和采集后2个时间点,两组供者呼吸和收缩压差异有显著性意义。提示非亲缘供者在采集过程中的心理负荷较高,应给予针对性情绪疏导指导和心理防护。

BACKGROUND：Currently, hematopoietic stem celltransplantation mainly depends on unrelated donors. Mental state of the unrelated donors is very important to ensure the successful celltransplantation. OBJECTIVE：To compare mental and physical health status of relative and unrelated donors during the hematopoietic stem cellcol ection. METHODS：We compared the mental （Symptom Checklist-90） and physical （temperature, breath, pulse, and blood pressure） health status of relative and unrelated donors at admission, 1 day before cellcol ection, and 1-2 days after cellcol ection.RESULTS AND CONCLUSION：At admission, there was no difference in the mental health status of relative and unrelated donors （P〉0.05）, while the scores on Symptom Checklist-90 were significantly higher in the unrelated donors than the relative donors, including total score, forced, depression, anxiety, hostility, and fear （P〈0.05）. The physical signs were steady in the unrelated and relative donors, but the difference in breath and systolic blood pressure was of great significance before and after cellcol ection in the two groups. These findings indicate that during cellcol ection, the unrelated donors exhibit heavier mental load than the relative donors, and psychological counseling and health guidance are necessary.