血管紧张素转化酶抑制剂治疗老年人慢性心力衰竭的有效性与安全性分析

Efficacy and safety analysis of angiotensin converting enzyme inhibitors in the treatment of elderly patients with chronic heart failure

目的探讨血管紧张素转化酶抑制剂(ACEI)治疗老年人慢性心力衰竭(CHF)的有效性与安全性。方法 76例老年CHF患者随机分为2组,对照组予利尿、扩血管等常规抗心衰治疗措施;观察组在此基础上联合应用贝那普利,比较2组患者治疗前后超声心动图指标及BNP、6 min步行距离等的变化。结果治疗后2组患者LVEDD、CO、LVEF均较治疗前有显著改善,且观察组优于对照组,差异有统计学意义(P<0.05);治疗后2组患者BNP及6 min步行距离均较治疗前有显著改善,且观察组优于对照组,差异有统计学意义(P<0.05)。结论 ACEI治疗老年人慢性心力衰竭可明显改善患者心功能、提高运动耐量、延缓心室重塑,且具有较好的用药安全性。

Objective To investigate the efficacy and safety of angiotensin converting enzyme inhibitors（ ACEI） in the treatment in elderly patients with chronic heart failure（ CHF）. Methods 76 elderly patients with CHF were randomly divided into control group and observation group. The control group was treated with diuretic,vasodilator and other conventional anti- heart failure treatment while the observation group was treated with benazepril based on the control group. The echocardiographic indicators and BNP,6min walking distance before and after the treatment were compared in the two groups. Results After treatment,the LVEDD,CO,LVEF,BNP and 6min walking distance were improved significantly compared with the treatment before in the two groups,and were better in the observation group than that in the control group,the difference was of statistically significant（ P〈 0.05）. Conclusion The treatment of ACEI in elderly patients with chronic heart failure can significantly improve the heart function,improve exercise tolerance and slow ventricular remodeling,so it enjoys a better medication safety.