婴幼儿原发性皮肤骨瘤4例临床及病理分析

Infant primary osteoma cutis:4 cases of clinicopathologic analysis

目的：探讨婴幼儿原发性皮肤骨瘤的临床病理特征。方法：大体及镜下观察，结合临床表现及x线检查并文献复习。结果：4例患儿，2男2女，年龄为5个月～4岁，临床表现为背部、颈部、腕部及腹股沟红褐色条索状及结节状皮疹。质硬。病理学特征：大体见切除皮肤局部稍高出皮面，质硬，边界清。镜检见真皮及皮下组织中见成片、成团分布的骨及骨样组织。由成熟编织骨组成，周围可见骨母细胞。结论：皮肤骨瘤指真皮或皮下组织内新骨形成，可分为原发性及继发性，该病为良性肿瘤，手术切除治疗效果好，未见恶变报道。

Objective： To study the clinicopathological characteristics of infant primary osteoma cutis. Methods： Physical examination, histopathology and radiograhy were used to study 4 cases of infant primary osteoma cutis, and the literatures were also reviewed. Results： Two boys and two girls, aged 5 months to 4 years old, presented with reddish brown firm cord-like and nodular lesions on the back, neck, wrist and groin. Histopathologieal examination revealed there were masses and pieces of bone and bone-like tissues composed of matured woven bones lined with osteoblasts in the dermis and subcutaneous tissue. Conclusion： Primary osteoma eutis refers to cutaneous ossification of dermis or subcutaneous tissue The condition has been divided into two subclasses： primary and secondary. Primary osteoma cutis is a benign tumor, surgical operation is effective and malignant change has not been reported.