摘要
目的探讨慢性肾小球疾病患者25-羟基维生素D3[25(OH)D3]水平的改变及意义。方法慢性肾小球疾病患者823例中,肾病综合征122例(14.7%),原发肾小球疾病463例(55.7%),高血压肾病35例(4.2%),糖尿病肾病50例(6.0%),狼疮性肾炎和血管炎导致的肾脏损害42例(5.1%),其他病因导致的肾脏损害111例(13.4%)。比较六组患者血清25(OH)D3水平、24-h尿蛋白及血白蛋白水平的差异。结果全组患者血清25(OH)D3水平为(28.8±21.6)nmol/L,白蛋白为(35.1±8.6)nmol/L,24-h尿蛋白(2.33±3.42)g。六组患者间血清25(OH)D3、白蛋白及24-h尿蛋白均存在统计学差异(P<0.05);肾病综合征组血清25(OH)D3最低[(12.7±10.1)nmol/L],24-h尿蛋白最高[(6.03±5.50)g]。结论在各类慢性肾小球疾病中,肾病综合征患者的25(OH)D3缺乏最为严重。
Objective To explore the changes and significance of serum 25-hydroxy vitamin D3 [25（OH）D3] in the patients with chronic glomerular diseases. Methods A total of 823 patients with chronic glomerular diseases was divided into 6 groups of A （nephrotic syndrome, 122 cases）, B （primaYy glomerular disease, 463 cases）, C （hypertensive nephropathy, 35 cases）, D （diabetic nephropathy, 50 cases）, E（lupus nephritis and vasculitis, 42 cases） and F（kidney damage resulted from the other causes, 111 cases）. Serum level of 25 （OH）D3,24-hour urine protein and serum albumin were compared among 6 groups. Results In 823 patients, serum 25（OH）D3 was （28. 8±21.6） nmol/L, serum albumin was （35.1±8.6） nmol/L,and 24-hour urine protein was （2.33±3.42） g,which were all significantly different among 6 groups（P〈0. 05）. Serum 25（OH）D3 in group A was （12.7±10. 1） nmol/L, which was the lowest among 6 groups（P〈0. 05）, and 24-hour urine protein in group A was （6.03±5.50） g,which was the highest among 6 groups（P〈0. 05）. Conclusion Of different kinds of chronic glomerular diseases, the deficiency of serum 25 （OH）D3 is of most severity in the patients with nephrotic syndrome.
出处
《江苏医药》
CAS
北大核心
2014年第14期1685-1687,共3页
Jiangsu Medical Journal
