脑钠肽在小儿心力衰竭中的水平变化及临床意义

Diagnostic Value of Brain Natriuretic Peptide in Pediatric Heart Failure

目的探讨脑钠肽(BNP)在小儿心力衰竭患儿中的水平变化对临床治疗评估的价值。方法将80例小儿心力衰竭患儿按照心衰分级标准随机分为A组(Ⅰ级)、B组(Ⅱ级)、C组(Ⅲ级)、D组(Ⅳ级)各20例,对各组患儿入院即刻及治疗1 w后检测BNP、心肌肌钙蛋白、血氧饱和度、心率水平进行对比分析评价其灵敏性。结果各组心力衰竭患儿入院即刻BNP、心肌肌钙蛋白、血氧饱和度、心率水平比较随分级升高而升高,P<0.05,具有显著性差异,呈正相关;治疗1 w后BNP、心肌肌钙蛋白、血氧饱和度、心率水平比较,P<0.05,具有显著性差异,呈正相关。结论血浆BNP水平变化可为临床治疗小儿心衰提供预后信息并可迅速准确进行治疗评价,具有可靠意义。

Objective To investigate the changes of plasma level and the diagnostic value of brain natriuretic peptide in pediatric heart failure. Methods According to heart failure grading standard,80 cases of children with heart failure were randomly divided into group A（Ⅰ）,group B（Ⅱ）,group C（Ⅲ） and group D（Ⅳ）（20 cases in each group）. The BNP,cardiac troponin,oxygen saturation,heart rate of patients after 1 week＇s treatment were detected and compared to evaluate the sensitivity. Results The BNP,cardiac troponin,oxygen saturation,heart rate of children with heart failure increased with grading,P〈 0. 05,there were significant differences and positive correlation. The same results emerged in patients after 1 week＇s treatment. Conclusion Changes of plasma BNP level can provide prognostic information for clinical treatment of pediatric heart failure and evaluate treatment quickly and accurately,which has reliable significance.