2011—2013年天津市宝坻区手足口病病原学变迁情况分析

Analysis on the Vicissitude of HFMD Etiology in Baodi District of Tianjin in 2011—2013

目的了解天津市宝坻区2011—2013年手足口病主要病原型别及其分布特征,为手足口病的防控提供病原学依据。方法采用荧光RT-PCR方法,对采集的临床诊断的手足口病病例粪便样本进行检测和型别鉴定。结果 157例临床诊断手足口病病例粪便标本中检出132例EV阳性病例,阳性率为84.08%,其中EV71阳性51例,CA6阳性38例,分别占EV阳性病例的38.64%、28.79%,占所有感染者的85.61%,不同性别间EV71、CA16、CA6、其他肠道病毒、CA16和其他肠道病毒混合感染阳性率差异无统计学意义,2011—2013年病原构成呈动态变化特征,不同病原交替主导。结论2011—2013年宝坻区手足口病的主要病原为EV71和CA6,病原交替主导,存在混合感染,应长期性、连续性地开展病原学监测。

Objective To analyze the etiological characteristics of hand,foot and mouth disease（ HFMD） in Baodi from 2011 to 2013,and to provide etiological basis for further control and prevention of HFMD. Methods The stool samples collected from patients with HFMD were detected and identified by fluorescent RT-PCR method. Results 132 EV cases of the 157 stool samples of HFMD cases were detected to be positive,and the positive rate was 84. 08%,of which 51 EV71 cases were positive,38 CA6 cases were positive,accounting for 38. 64% and 28. 79% of EV positive cases,and 85. 61% of all the infected respectively. There were no statistic significance as for the differences of infection positive rates among EV71,CA16,CA6 in different genders and other enterovirus and the mixed infection between CA16 and other enterovirus. The pathogen compositions from 2011 to 2013 was dynamic,and they dominated alternatively. Conclusion The major pathogens of HFMD in Baodi District from 2011 to 2013 were EV71 and CA6,which dominated alternatively and posed the possibility of mixed infection,thus,the long-term and continuous etiological surveillance for HFMD should be carried out.