HER2蛋白在乳腺癌靶向治疗中的作用及意义

Effect and significance of HER2 protein in breast cancer targeted therapy

近年来,分子生物学在医学领域得到了充分的发展,分子靶向治疗成为治疗肿瘤的一个新方向。酪氨酸激酶受体家族调控着细胞增殖、分化以及凋亡,与肿瘤的发生与发展密切相关,是一个较为理想的特异性靶点。约有30%的乳腺癌患者出现了人表皮生长因子受体2(HER2)过表达,而HER2受体的活化直接导致了其下游的PI3K/AKT和丝裂原活化蛋白激酶(MAPK)通路被激活,而通过靶向HER2过表达的细胞对肿瘤进行控制成为了一种新的乳腺癌的治疗手段。

In recent years, molecular biology has been fully developed in medical domain, which makes molecular targeted therapy possible in treating tumor. Tyrosine kinase receptors have regulation of cell proliferation, differentiation and apoptosis, and also have relationship with the occurrence and development of tumor. Therefore, tyrosine kinase receptors have become ideal specific target. Among the breast cancer patients, there were 30% of them have human epidermal growth factor receptor （HER2） overexpression. The activated HER2 receptors directly cause the activation pathway of PI3K/AKT and mitogen activated protein kinase （MAPK）. Therefore, targeted therapy on the cells with HER2 overexpression has been a new method to cure breast cancer.