地氯雷他定对过敏性哮喘豚鼠模型肺泡灌洗液IL-4和IL-13水平的影响

Effects of desloratadine on the levels of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rats model

目的研究地氯雷他定对过敏性哮喘豚鼠模型肺泡灌洗液IL-4和IL-13水平的影响。方法用卵蛋白造成过敏性哮喘豚鼠模型,观察地氯雷他定对过敏性哮喘豚鼠哮喘潜伏期、肺泡灌洗液IL-4和IL-13水平的影响。结果地氯雷他定能显著延长过敏性哮喘豚鼠哮喘潜伏期,明显降低肺泡灌洗液IL-4和IL-13水平。结论地氯雷他定能通过降低细胞因子IL-4和IL-13水平来延缓哮喘的发作,为其临床治疗哮喘提供实验依据。

Objective 5BTo study the effects of desloratadine on the level of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rat model. Methods The allergic asthmatic rat model was induced by ovalbumin. Then the effects of desloratadine on the latent period of asthma,the level of IL-4 and IL-13 in bronchoalveolar lavage fluid were observed. Results Desloratadine could extend the latent period of asthma,and decrease the level of IL-4 and IL-13 in bronchoalveolar lavage fluid. Conclusion Desloratadine could delay the onset of asthma by decreasing the level of IL-4 and IL-13. So it provides basis for the clinical use in treating asthma.