检测血清超敏C反应蛋白在原发性高血压中的临床意义

Clinical significance of detection of serum high sensitivity C-reactive protein of patients with primary hypertension

目的探讨原发性高血压患者检测血清超敏C反应蛋白(hs-CPR)水平的临床意义。方法选择原发性高血压患者152例,按高血压分级分为3组,嘱予低盐低脂饮食、适当锻炼等生活调理,给予常规降压治疗。观察半年,对观察期前后的hs-CPR水平进行对比,并与健康人群进行对比。结果观察期前后高血压组血清hs-CRP水平显著高于健康人群组(P<0.01);入组时高血压2级、3级组血清hs-CRP水平显著高于高血压1级组(P<0.05)。观察期满后,高血压1级、2级、3级组血清hs-CRP水平显著低于各自入组时(P<0.05);高血压2级、3级组血清hs-CRP水平显著高于高血压1级组(P<0.05)。结论原发性高血压患者具有明显增高的血清hs-CPR水平,血清hs-CPR与高血压的发生强烈相关。有效控制血压可明显降低其水平。

Objective To investigate clinical significance of detection of serum high sensitivity C-reactive protein（hs-CPR） of patients with primary hypertension. Methods A total of 152 patients with primary hypertension were divided into 3 groups according to the classification of hypertension. All patients were suggested to have low-salt and low-fat diet and proper physical exercise and received antihypertensive therapy. After half a year,hs-CPR levels before and after observation period were analyzed and compared with healthy people. Results Levels of hs-CRP before and after observation period were higher than that of healthy people（P〈0. 01）. The hs-CRP levels of level 2 and level3 of hypertension were obviously higher than level 1 of hypertension before grouping（P〈0. 05）. After observation period,hs-CRP levels of level 1,level 2 and level 3 of hypertension were significantly lower than that before grouping in each group（P〈0. 05） while level 2 and level 3 were markedly higher than that of level 1（P〈0. 05）. Conclusion Primary hypertension has obviously increased hs-CRP and hs-CRP,so they have a strong relationship with the occurrence of hypertension. Therefore,effective control of blood pressure can obviously reduce the hs-CRP level.