纳洛酮治疗急性安定中毒的疗效分析

Clinical therapeutic effect of Naloxone for acute poisoning by Diazepam

目的探讨纳洛酮治疗急性安定中毒患者的临床效果。方法将98例急性安定中毒患者随机分为治疗组和对照组两组,两组各49名患者,均进行洗胃、利尿等综合治疗,同时给予吸氧、保暖,并纠正水、电解质及酸碱平衡,治疗组加用纳洛酮进行治疗,对照组采用常规治疗,观察两组患者意识恢复时间及疗效。结果治疗组患者意识的恢复时间少于对照组,差异均有统计学意义(P均<0.05);治疗组的治疗有效率高于对照组,两组间差异有统计学意义(P<0.05)。结论使用纳洛酮治疗安定中毒,效果良好,可在临床上推广使用。

Objective To discuss the clinical effect of Naloxone in the treatment of acute poisoning by diazepam.Methods 98 patients were divided into two groups randomly and each group had 49 patients.Each patient was given general treatment including gastric lavage , diureses, aspiration and to keep body warm , at the same times, correction of adic-base, fluid and electrolyte imbalance .Then the experimental group was given Naloxone, while the control group was given conventional therapy .This study compared the consciousness recovery time of the two groups .Results The consciousness recovery time of the experimental group was less than the control group, there was significant difference between the two groups （P〈0.05）; the effective power of the the experimental group was higher than the control group , there was significant difference between the two groups （P〈0.05）.Conclusions The therapeutic effect naloxone for acute poisoning by Diazepam is good , can be used widely in clinic .