低纳血症对重症病毒性肝炎并多器官功能衰竭预后的影响

Effect of hyponatremia on prognosis of fulminant viral hepatitis with multiple organs failure

目的探讨低纳血症对重症病毒性肝炎并多器官功能衰竭(MOF)预后的影响。方法对继发低纳血症的51例重型病毒性肝炎并多器官功能衰竭患者与无低钠血症的35例重型病毒性肝炎并多器官功能衰竭患者进行回顾性分析。结果继发低钠血症的重型病毒性肝炎并多器官衰竭患者总胆红素明显高于无低钠血症的重型病毒性肝炎并多器官衰竭患者(P<0.01),凝血酶活动度(PTA)低于无低钠血症的重型病毒性肝炎并多器官衰竭患者(P<0.05),病死率为25.49%,明显高于无低钠血症的重型病毒性肝炎并多器官衰竭患者(P<0.05)。结论低钠血症增加重型病毒性肝炎并多器官衰竭患者的死亡率。

Objective To explore the effect of hyponatremia of the fulminant viral hepatitis with multiple organs failure.Methods 51 cases of the secondary hyponatremia and 35 without hylminant viral hepatitis with multiple organs failure were analyzed retrospectively in this paper .Results The total bilirubin（P〈0.01）, the fatality rate（25.49%） of the secondary hyponatremia in fulminant viral hepatitis with multiple organs failure were much higher that of no hyponatremin in fulminant viral hepatitis with multiple organs failure , and the serozyme activity（PTA） was mush lower （P〈0.05）.Conclusions Hyponatremia may increase the fatality rate of the fulminant viral hepatitis with multiple organs failure .