回顾性分析伊曲康唑注射液治疗恶性血液病侵袭性真菌感染的疗效

Retrospeaive study of intravenous itraconazole in treatment of invasive fungal infection in hematologic malignancies

目的回顾性分析伊曲康唑注射液治疗血液系统恶性肿瘤继发侵袭性真菌感染(IFI)疗效及安全性。方法入选我院血液科收治的血液系统恶性肿瘤伴发IFI患者69例,用伊曲康唑注射液200 mg,q12 h,疗程超过14 d,评价其疗效及安全性。结果痊愈或显效60例(87.0%);出现不良反应13例(18.8%),其中9例(70%)为用药14 d前发生。结论长程用伊曲康唑注射液疗效明确,安全性较好。

Objeetive To investigate the efficacy and safety of long -term intravenous itraconazole for the treatment of invasive fungal infection （ IFI） in patients with hematological malignancies.Methods Sixty -nine patients with above mentioned conditions and diagnosed as IFI was administered at a dose of 200 mg every 12 hours for 2 days and followed by 200 mg every 24 hours at least 14 days.Responses were determined on the basis of clinical and microbiological criteria.Results The total response rates related to itraconazole among the IFI patients were 87.0%（60/69）.Adverse effects rates were 18.8%, and 70% adverse effects happened winthin the first 14 days after intravenous itraconazole adminis-tered.Conclusion Long -term intravenous intraconazole antifungal treatment is effective and safe for hematologic malignancies with IFIs.