缬沙坦治疗老年单纯收缩期高血压的临床疗效及其对胰岛素抵抗的影响

Effects of valsartan on blood pressure and insulin sensitivity in aged patients with isolated systolic hypertension

目的评价缬沙坦治疗老年患者单纯收缩期高血压(ISH)的临床疗效及其对患者胰岛素抵抗的影响。方法 89例ISH患者口服缬沙坦80 mg·d-1,疗程为8周,治疗期间随访记录患者的血压、空腹胰岛素、胰岛素敏感指数及药物相关不良反应。结果 81例患者完成预定研究,8例失访。患者口服缬沙坦1周后收缩压开始明显降低,8周后收缩压明显低于治疗前(P<0.05);治疗结束时,患者空腹胰岛素水平和胰岛素敏感指数明显低于治疗前(P<0.05)。随访期间出现眩晕4例,咳嗽2例,不良反应总发生率为6.7%。结论缬沙坦可有效控制老年单纯收缩期高血压,增加胰岛素敏感性,药物不良反应轻微。

Objective To evaluate clinical efficacy of valsartan on the blood pressure and insulin sensitivity in aged patients with isolated systol-ic hypertension （ISH）.Methods Eight -nine patients with ISH were recruited for the prospect clinical trials .All the patients were given val-sartan 80 mg· d-1 for two month.The blood pressure （ BP） , fasting in-sulin （ FINS ） , insulin sensitive index （ ISI ） and related side effects of this drug were all recorded in the procedure of treatment.Results Eighty-one patients finished the clinical trial.The blood pressure began to decrease after one -week administration and the blood pressure was significantly decreased at the end of the trial compared with the initial condition （ P〈0.05 ）.The fasting insulin levels and insulin sensitivity indexes were significantly decreased after two -month treatment （ P 〈0.05 ）.Four cases of dizziness and two cases of cough were reported in the procedure of treatment , with an incidence rate of 6.7%.Conclu-sionValsartan can significantly decrease the blood pressure and increase the insulin sensitivity in aged patients with ISH with slight side effects.