酒精与肝脏脂质代谢

Alcohol and hepatic lipid metabolism

酒精滥用是一个重大的公共健康问题。酒精通过刺激脂肪酸合成,抑制脂肪酸的氧化导致肝脏脂质积累,进而诱发肝细胞病变,导致脂肪肝的病发。从转录调控脂质代谢的改变,异常甲硫氨酸代谢对内质网应激反应的作用等方面概述酒精与脂质代谢的相互调控机制,并阐述了这些调控机制之间的内在联系以及酒精如何影响肝脏脂质代谢,从而导致脂肪肝形成的最新相关研究进展。

Alcohol abuse is a major public health problem. Alcohol induces lipid accumulation in hepatocyte by stimulating lipid synthesis and inhibiting lipid oxidation, further induces hepatocytes lesions and finally leads to the development of steatosis. This review summarized mechanisms of effects of alcohol on lipid metabolism, including alterations of transcriptional regulation of lipid metabolism, effects of abnormal methionine metabolism on the endoplasmic reticulum stress. Then we elaborated intrinsic link among these mechanisms, and how alcohol deranges hepatic lipid metabolism and then leads to the development of fatty liver.