O-GlcNAc修饰对蛋白质泛素化降解途径的影响

O-GlcNAcylation influences ubiquitin proteasome degradation of protein

O-GlcNAc修饰是一种特殊的糖基化修饰,几乎参与生物体内所有细胞过程的调控。该修饰与泛素化作为两种重要的蛋白质翻译后修饰形式,都与2型糖尿病、神经退行性疾病、癌症等疾病密切相关。O-GlcNAc修饰对蛋白质泛素化降解途径的影响主要体现在4个方面:(1)O-GlcNAc修饰能够抑制26S蛋白酶体的ATPase活性;(2)O-GlcNAc修饰会减少某些底物蛋白的泛素化降解;(3)O-GlcNAc修饰泛素化相关酶并调节其功能;(4)某些蛋白质(包括调控因子)发生O-GlcNAc修饰后间接影响蛋白质泛素化。

O-GlcNAcylation is a special protein glycosylation, which plays crucial roles in various cellular events. Both O-GlcNAcylation and ubiquitination are important post-translational modification. They are closely related to type 2 diabetes, neurodegenerative diseases, cancer and other diseases. The cross-talk between O-GlcNAcylation and ubiquitination could be divided into four categories： （1） O-GlcNAcylaion of the 26S proteasome regulatory subunit inhibits its ATPase activity; （2） O-GlcNAcylaion on some proteins could decrease their ubiquitin proteasome degradation; （3） O-GlcNAcylation of ubiquitination enzymes regulates their functions; （4） O-GlcNAcylation on some protein （including regulatory factors） affects ubiquitination process indirectly.