131^碘治疗Graves病患者后TGAb与TPOAb变化的意义

Significance of the changes of TGAb and TPOAb levels in Graves hyperthyroidism patients after 131 I treatment

目的：对131^碘治疗Graves甲状腺功能亢进（以下简称甲亢）患者后甲状腺球蛋白抗体（ TGAb）、甲状腺过氧化物酶抗体（ TPOAb）变化的意义进行分析与探讨。方法选取2012年7月至2013年6月在山西医科大学第三医院接受治疗的 Graves 甲亢患者100例，并在治疗前与采用131碘进行3、6、12个月的治疗后对患者血清TGAb、TPOAb进行检测。依照临床转归具体情况将患者分为复发组、甲状腺功能减低组及正常组。结果对患者进行相应治疗后，复发组与甲状腺功能减低组患者TGAb、TPOAb检测值明显高于正常组，差异有统计学意义（ P﹤0.05）。结论对患者血清TGAb、TPOAb浓度进行检测对131^碘对Graves甲亢的治疗存在非常重要的指导意义。

Objective To analyze and investigate the significance of the change of TGAb and TPOAb in Graves hyperthyroidism patients after 131 I treatment. Methods One hundred Graves hyperthy-roidism patients treated in the third hospital of Shanxi medical university from July 2012 to June 2013 were selected,and the serum TGAb and TPOAb levels were tested before treatment and 3,6 and 12 months after 131 I treatment. And the patients were divided into recurrence group,hypothyroidism group and normal group in accordance with clinical outcome. Results After treatment,the levels of TGAb and TPOAb in recurrence group and hypothyroidism group were significantly higher than those in nor-mal group,the differences were significant（P﹤0. 05）. Conclusions Detection of the levels of se-rum TGAb and TPOAb has very important guiding significance in 131 I treatment for Graves hyperthy-roidism.