翼状胬肉的不同术式对角膜上皮修复及复发率的影响

Effects of two methods for primary pterygium on corneal epithelial repairment and recurernce rate

目的：比较单纯翼状胬肉切除术与翼状胬肉切除术加自体角膜缘干细胞移植两种手术方式治疗原发性翼状胬肉的临床疗效。方法选择原发性翼状胬肉患者83例（92眼），A组41例（46眼）行单纯翼状胬肉切除术，术中应用丝裂霉素C；B组42例（46眼）行翼状胬肉切除加自体角膜缘干细胞移植。术后随访6-12个月，比较两组患者术后角膜创面愈合、角膜散光及复发情况。结果角膜荧光染色显示A组、B组角膜创面平均愈合时间分别为7.34 d和6.32 d，差异有统计学意义（ P﹤0.05）。术后3个月两组患者的角膜散光度比较差异无统计学意义（ P﹥0.05）。A组复发8眼（复发率为17.4%），B组2眼（复发率为4.3%），两组比较差异有统计学意义（ P﹤0.05）。结论翼状胬肉切除术加自体角膜缘干细胞移植手术方式优于单纯翼状胬肉切除术。

Objective To compare the clinical effects of Pterygium excision and autologous corneal limbal stem cell tran splantation combined with pterygium excision on primary pterygium. Methods Eighty-three patients（92 eyes） with primary pterygium were chose,41 patients（46 eyes）in group A were given simple pterygium excision,with MMC used during the operation,42 patients（46 eyes）in group B were given autologous corneal limbal stem cell transplantation combined with pterygium excision. The post-operative follow-up periods ranged from 6-12 months. The corneal wouds healing,corneal astigmia and the recurrent rate of the two groups were compared. Results The average corneal wouds healing time was 7. 34 d in group A and 6. 32 d in group B,there was significant difference between the two groups（ P﹤0. 05 ）. There was no significant difference in the corneal astigmia degree between the two groups at 3 months after operation（ P﹥0. 05）. The recurrent rate was 17. 4%（8 eyes）in group A and 4. 3%（2 eyes）in group B,there was significant difference between the two groups（ P﹤0. 05 ）. Conclusions The method of pterygium excision combined with autologous corneal limbal stem cell transplantation is superior to single pterygium excision.