白癜风皮损浸润细胞CD分子表达的初步研究

A study of CDs infiltrating cells expressions in patients with segmental and non-segmental vitiligo

目的：探讨寻常型和节段型白癜风CD分子表达的差异。方法应用免疫组织化学方法检测CD3、CD4、CD8、CD20、CD45RO、CD68和CD79α在白癜风皮损中的表达。结果寻常型与节段型白癜风皮损中 CD3、CD4、CD8和CD45RO浸润细胞数均明显高于正常对照组，差异有统计学意义（P﹤0.01）；寻常型及节段型白癜风皮损中CD20、CD79α和CD68浸润细胞数与正常对照组比较差异无统计学意义（ P﹥0.01）。结论寻常型与节段型白癜风存在CD3、CD4、CD8及CD45RO的免疫参与，可能与白癜风的免疫发病机制有关。

Objective To investigate the differences of CDs infiltrating cells expressions in seg-mental and non-segmental vitiligo. Methods The expressions of CD3,CD4,CD8,CD20,CD45RO, CD68,CD79a were detected by immunohistochemical staining. Results The expressions of CD3 , CD4 ,CD8 and CD45 RO of the infiltrating cells in both non-segmental and segmental vitiligo were significantly higher than those of normal control group,the differences were statistically significant （ P﹤0. 01 ）;the expressions of CD20 ,CD79αand CD68 of infiltrating cells both in segmental and non-segmental vitiligo were same as normal control group,the difference was not statistically signifi-cant（ P﹥0. 01 ）. Conclusions CD3 ,CD4 ,CD8 ,CD45 RO and CD68 are related to immune re-sponse both in segmental and non-segmental vitiligo.