CD207在白癜风发病机制中的作用研究

The role of CD207 in the pathogenesis of vitiligo

目的：观察白癜风皮损中CD207的表达，探讨白癜风的免疫发病机制。方法采用免疫组织化学法检测12例节段型白癜风、25例寻常型白癜风和10例正常皮肤组织中CD207的表达水平，并比较其差异性。结果节段型白癜风组、寻常型白癜风组表皮内CD207表达分别为（61.2±10.9）和（64.3±12.5）个/mm，均高于正常对照组（52.4±0.3）个/mm，差异有统计学意义（P﹤0.05）。节段型白癜风组与寻常型白癜风组相比，CD207表达差异无统计学意义（ P﹥0.05）。结论节段型白癜风、寻常型白癜风皮损组织中CD207的表达高于正常对照组，提示其发病机制与朗格汉斯细胞参与的细胞免疫反应有关。

Objective To observe the expression of CD207 in the lesions of vitiligo and the immune pathogenesis of vitiligo. Methods The CD207 expression level was detected by immunohistochemistry in 12 patients with segmental vitiligo,25 patients with vitiligo vulgaris and 10 normal skin tissues,and the results were compared. Results The expression of CD207 in segmental vitiligo group and vitiligo vulgaris group was（61. 2 ± 10. 9） and（64. 3 ± 12. 5）count/mm respectively,（52. 4 ±10. 3）count/mm in control group. The differences were statistically significant（ P﹤0. 05 ）. Conclusions The expression of CD207 in the lesions of segmental vitiligo and vitiligo vulgaris is higher than that in the normal control group,indicating that the mechanism of vitiligo is associated with the cellular immunity response which langerhans cell was involved.