生血宁片联合复方硫酸亚铁叶酸片在妊娠期缺铁性贫血治疗中的应用研究

Application Research of Shengxuening Tablets Combined with Compound Ferrous Sulfate and Folic Acid Tablets for Iron Deficiency Anemia in Pregnancy Period

目的:探讨生血宁片联合复方硫酸亚铁叶酸片在妊娠期缺铁性贫血治疗中的临床价值。方法:选择本院确诊为妊娠期缺铁性贫血的孕妇84例,按照随机数字表法分为2组各42例,对照组给予饮食、营养指导,同时给予复方硫酸亚铁叶酸片治疗;观察组在对照组基础上加用生血宁片治疗,观察2组临床疗效以及相关指标变化。结果:2组患者治疗后红细胞计数(RBC)、血红蛋白(Hb)、平均血红蛋白浓度(MCHC)、平均红细胞体积(MCV)等血液学指标和血清铁(SI)、转铁蛋白饱和度(TSAT)等铁代谢指标比较,差异均有显著性意义(P<0.05),且观察组改善优于对照组(P<0.05)。对照组显效率38.1%、总有效率69.0%,观察组显效率61.9%、总有效率90.4%,观察组不良反应显著低于对照组(P<0.05)。结论:生血宁片联合复方硫酸亚铁叶酸片治疗妊娠期缺铁性贫血疗效确切,不良反应少,值得在临床应用。

Objective： To investigate the clinical effect of Shengxuening tablets combined with Compound Ferrous Sulfate And Folic Acid Tablets（CFSFAT）for iron deficiency anemia during pregnancy period. Methods： A total of 84 cases of pregnant women who had been diagnosed as iron deficiency anemia were divided into two groups according to the random number. The control group was told to follow the dietary and nutrient guidance and was given CFSFAT orally, and the observation group was treated with Shengxuening tablets based on the treatment for the control group. The clinical efficacy between the two groups and the related indexes were compared. Results： The differences of the corpuscular indexes of red blood cell （RBC） count, hemoglobin（Hb） content, mean corpuscular hemoglobin concentration（MCHC）, and mean corpuscular volume （MCV）, as well as the iron metabolism indexes of serum iron（SI） and transferrin saturation（TSAT） were found to be statistically significant between the two groups after treatment（P 〈 0.05）. The markedly effective rate was 38.1% and effective rate was 69.0% in the control group, and was 61.9%, 90.4% in the observation group, the difference being significant（P 〈 0.05）. The adverse reaction incidence was 4.8% in the observation group, and was 21.4% in the control group, the difference being significant（P 〈 0.05）. Conclusion： Shengxuening tablets combined with CFSFAT are effective and safe for the treatment of iron deficiency anemia during pregnancy period, and are worthy in the clinical application.