肺癌化学药物预防的研究进展

Research progress on lung cancer chemoprevention

肺癌是世界范围内癌症致死的首要原因。近年来，针对肺癌的传统治疗手段虽不断发展和改善，但肺癌的病死率未明显改变。除了大力倡导戒烟，化学药物预防有望降低肺癌的发生及抑制肺癌的发展，从而成为近年来研究的热点。化学药物预防是应用饮食和／或药物来抑制或逆转肿瘤的形成，目前已成功用于某些恶性肿瘤的临床预防。虽然已有的研究未能找到有效预防肺癌的药物，但鉴于大部分肺癌的发生是支气管上皮经历正常分化、增生、化生、异常增生及癌变的过程，故找寻可以有效抑制或逆转癌前病变或癌前状态的药物就变得愈发重要。

Lung cancer is the leading cause of cancer death in the world. Most patients with lung cancer are not candidates for curative therapy, and new therapies have not made a substantial impact on survival. Chemoprevention can reverse or inhibit the carcinogenic process through the use of dietary or pharmaceutical agents and has been successfully applied to common malignancies other than lung. Despite previous studies in lung cancer chemoprevention failing to identify effective agents,since the development of most lung bronchogenic carcinoma in the central bronchial epithelium starts with normal epithelium and progresses through hyperplasia, metaplasia, dysplasia, carcinoma in situ to invasive lung cancer. It is needed for effective lung cancer chemoprevention to reverse or inhibit the premalignant lesions.