硫化氢在呼吸中的作用

Role of hydrogen sulfide in respiration

硫化氢（hydrogen sulfide，H2S）是一种具有特殊臭味的有毒气体。然而，近年来发现H2S是生物体内继NO、CO之后的第3种内源性气体信号分子，具有调节呼吸节律、在颈动脉体感受低氧、在呼吸中枢抗低氧，从而在机体低氧状态下实现稳态调节的生理作用。研究表明，H2S参与肺损伤、肺动脉高压、支气管哮喘及COPD等呼吸疾病过程，且多具有抗炎、抗氧化损伤等作用。

Hydrogen sulfide （H2S） is a toxic and special smell gas for human. However,in recent years H2S is found as the third endogenous gaseous signal molecule following NO and CO. H2S has physiological effects in vivo： respiratory rhythm regulation, feeling hypoxia in the carotid body and anti-hypoxia protecting the respiratory center, so achieving the body homeostasis in hypoxia. H2 S is involved in the pathophysiological processes of lung injury, pulmonary hypertension, bronchial asthma, chronic obstructive pulmonary disease and other respiratory diseases, and has such effects as anti-inflammatory and anti-oxidative damage.