呼吸道合胞病毒感染的动物模型特点及其应用

Animal model of respiratory syncytial virus infection and its characteristics and applications

呼吸道合胞病毒（RSV）是世界范围内婴幼儿下呼吸道感染最常见的病原，RSV感染也是2岁以下婴幼儿病毒感染性疾病最常见的死因，严重威胁健康，迫切需要发展有效的RSV疫苗和抗病毒药物。然而，对人类免疫系统在RSV感染发病机制、易感性和疫苗安全等方面缺乏深入的了解，限制了RSV预防和治疗的研究。各种动物模型的发展可以更好地研究RSV相关疾病的发病机制以及各类预防和治疗药物。本文综述现有的RSV感染动物模型特点及其应用。

Respiratory syncytial virus （RSV） is the most common pathogen which causes lower respiratory tract infections in infant worldwide. RSV infection is also the main cause of death in viral infectious disease in those under two years old, and poses a serious threat to health. There is an ugent need to develope effective RSV vaccine and antiviral drugs. However, the lack of thorough understanding about the pathogenesis, susceptibility,and vaccine safety in human limits the research in prevention and treatment of RSV infection. With the development of various animal models, people can do more better research in the pathogenesis of RSV-associated diseases and a variety of drugs which are used for prevention and therapy. This review focuses on the characteristics of RSV-infected animal models and its application.