多黏菌素的研究进展与临床应用

Clinical application and research progress of polymyxins Chao

随着多耐药革兰阴性杆菌不断出现，这类超级细菌对目前除多黏菌素之外其他抗菌药物全部耐药，使临床医师重新关注多黏菌素的应用。目前仅有多黏菌素B和多黏菌素E（黏菌素）用于临床。最近研究与应用较多的为黏菌素。因此，临床医师需要熟悉黏菌素的使用，最大限度提高疗效、降低耐药性的产生和避免不良反应。

The emergence of multidrug-resistant gram-negative bacteria and the lack of new antibiotics to combat them have led to the revival of polymyxins. Polymyxin B and polymyxin E （colistin） are the 2 polymyxins used in clinical practice. Most of the reintroduction of polymyxins during the last few years is related to colistin. In order to maximize the efficacy, minimize the development of resistance and avoid toxicity,we should be familiar with polymyxin.