优化β-内酰胺类抗菌素在重症医学中的应用——为患者制定个体化抗菌素治疗方案

Optimizing β-Iactam antibiotic therapy in the critically ill ：moving towards patient-tailored antibiotic therapy

感染依然是重症医学领域的重要问题之一。β-内酰胺类抗生素由于其强大的抗菌活性和极其有限的药物毒性，仍然被广泛的应用于临床治疗各种细菌感染。本综述旨在讨论β-内酰胺类抗生素应用于重症患者后治疗失败的相关原因，论证优化β-内酰胺类抗生素给药方式的必要性及达到这一目标的方法。讨论延续性输注β-内酰胺类抗生素治疗的可能的优点及潜在的风险及应用方法。最后，将更进一步提出抗生素治疗优化理论：抗生素治疗的个体化选择。

Infection is still one of the important issues in the field of critical care medicine. β- lactam antibiotics due to its strong antimicrobial activity and very limited toxicity, is still widely used in the clinical treatment of a variety of bacterial infections. This review aims to discuss the reasons for the β- lactam antibiotics used in critically ill patients with treatment failure,demonstrate the need to optimize lactam antibiotics administration and methods to achieve this goal. Possible advantages of continuity of discussion infusion β-laetam antibiotics and the potential risks and application methods. Finally, the proposed further antibiotic treatment optimization theory：antibiotic treatment of individual choice.