LEEP刀锥切术对宫颈癌患者生育能力和妊娠结局的影响

Impact on the fertility and pregnancy of patients with cervical cancer of LEEP knife conization

目的:探究宫颈LEEP刀锥切术对宫颈CINI-Ⅲ患者生育能力和妊娠结局的影响。方法:选择我院妇科2009年2月至2011年2月收治的50例早期宫颈癌患者和同期孕前门诊就诊的50例无宫颈锥切术史的计划妊娠妇女为研究对象。比较两组女性生育能力和母婴结局。结果:实验组50例患者有49例(96%)妊娠,对照组50例患者有42例(84%),差异有显著性(P<0.05);实验组50例患者有8例(16%)不孕,对照组50例患者有1例(2%)不孕,差异有显著性(P<0.05);实验组患者剖宫产率明显高于对照组,差异有显著性(P<0.05);实验组胎膜早破、早产、新生儿窒息和新生儿低体重均明显高于对照组患者的,差异有显著性(P<0.05)。结论:宫颈LEEP刀锥切术后宫颈CINI-Ⅲ妊娠率较正常人群稍差,而且也在一定程度上增加胎膜早破、胎儿早产、新生儿窒息和新生儿低体重的发生率。

To investigate the impact on the fertility and pregnancy of patients with cervical cancer by cervical LEEP knife conization.Methods：50 patients with early cervical cancer and 50 outpatients with-out cervical conization history and planned for pregnancy in our hospital from February 2009 to February 201 1 were chosen as the study objects.Female fertility and pregnancy outcome of the 2 groups were compared.Results：There were 49 pregnancy women （pregnancy rate of 96%）in the experimental group and 42 pregnancy women （pregnancy rate of 84%）in the control group,with significant difference （P〈0.05 ）.There were 8 cases of infertility in the experimental group （infertility rate of 16%）and 1 case of infertility in the control group （infertility rate of 2%）, with significant difference （P〈0.05 ）.The rate of cesarean section in the experimental group was significantly higher than that in control group,which was of significant difference （P〈0.05）.Premature rupture of fetal mem-branes,premature delivery,neonatal asphyxia and neonatal low birth weight of experimental group were significantly higher than those in control group,which was significant difference （P〈0.05 ）.Conclusion：Cervical CINI-III pregnancy rate after cervical LEEP knife conization is lower than the normal population,but it also increases the in-cidence of premature rupture of fetal membranes,premature birth,neonatal asphyxia and low birth weight.