梅毒血清试验阳性的女性不孕症临床分析

Clinical analysis of female infertility patients with positive syphilis serum test result

目的：探讨有梅毒血清试验阳性史的女性不孕症患者对其妊娠和胎儿的影响。方法：分析2006年1月-2012年6月在我院生殖中心就诊的女性不孕症患者的临床资料，随访有梅毒血清试验阳性史患者的妊娠及新生儿情况。结果：梅毒血清试验阳性者169例（1．40％）：RPR阳性／TPPA阴性4例，RPR阴性／TPPA阳性19例，RPR、TPPA均阳性146例；经驱梅治疗后，梅毒血清试验阳性者42例：RPR阳性／TPPA阴性2例。RPR阴性／TPPA阳性13例，RPR、TPPA均阳性27例。98例患者通过辅助生殖成功怀孕，83例分娩出正常新生儿，16例在孕期；12例新生儿梅毒血清试验阳性，经驱梅治疗后10月内均转阴性，所有新生儿均无明显异常。结论：女性不孕症患者中梅毒血清试验阳性的检出较高；有梅毒血清试验阳性的女性不孕症患者，通过规范驱梅或实验性治疗后，可进行辅助生殖且娩出健康的新生儿。

To study the influence of syphilis serum test positive on pregnancy and fetus of fe-male infertility patients.Methods：To analyze the data of female infertility patients visiting our reproductive medi-cine center from January 2006 to June 2012,and follow up the pregnancy and neonatal of syphilis serum test positive patients.Results：In 169 cases （1.40%）of syphilis serum test positive specimens,there were 4 cases of RPR pos-itive and TPPA negative,19 cases of RPR negative and TPPA positive,146 cases of RPR positive and TPPA posi-tive.After antisyphilitic treatment,there were 2 cases of RPR positive and TPPA negative,13 cases of RPR nega-tive and TPPA positive,and 27 cases of RPR positive and TPPA positive.98 patients were conceived by assisted re-productive;86 patients had delivered normal newborns;16cases were in pregnancy.12 neonates with positive syphi-lis serum test results all became negative 10 months later after antisyphilitic treatment.Conclusions：The syphilis serum test positive rate of female infertility patients is high;Female infertility patients of positive syphilis serum test results can be assisted for reproduction with antisyphilitic treatment.