血清IL-17在支气管哮喘患儿中的表达意义

Significance of Serum IL-17 Expression in Children with Bronchial Asthma

目的探讨血清白细胞介素-17(IL-17)在支气管哮喘患儿中的表达意义。方法 106例支气管哮喘患儿作为研究对象,42例急性发作期患儿作为A组,64例慢性缓解期患儿作为B组,40例健康儿童作为C组。测定血清IL-17和C反应蛋白(CRP)。结果 B组和C组血清IL-17和CRP无明显差异(t=0.7128、0.4426,P>0.05),A组血清IL-17和CRP均高于B组和C组(t=9.3648、7.0614、10.7716、9.6242,P<0.01)。A组患儿血清IL-17与CRP有明显正相关关系(r=0.7026,P<0.05)。治疗4周后随访40例,血清IL-17为(152.3±21.6)ng/L;治疗后血清IL-17明显降低(t=8.7728,P<0.01)。结论血清IL-17可以用于监测支气管哮喘急性发作期患儿的炎症状态,判断患儿预后。

Objective To study the significance of serum interleukin-17 （IL-17） expression in children with bronchial asthma. Methods 106 cases of bronchial asthma in children were enrolled as research subjects. 42 cases of acute exacerbation of children were enrolled as group A, 64 cases of children with chronic remission as group B, 40 healthy children as group C. Serum IL-I7 and C-reactive protein （CRP） were detected. Results Serum IL-17 and CRP was no significant difference between group B and group C （t=0.7128,0.4426,P〉0.05）. Serum IL-17 and CRP in group A were higher than group B and group C （t=-9.3648, 7.0614, 10.7716, 9.6242, P〈0.01）. Serum IL-17 and CRP in group A had significantly positive correlation （r=0.7026, P〈0.05）. After 4 weeks of treatment follow-up of 40 patients, serum IL-17 was （152.3±21.6）ng/L and after treatment, serum IL-17 was significantly lowered （t=-8.7728, P〈0.01）. Conclusions Serum IL-17 can be used to monitor children with bronchial asthma in acute exacerbation of inflammatory state, and to determine the prognosis of children.