期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张素Ⅱ1型受体与内质网应激在糖尿病肾病中的研究进展 被引量：4

Progress in the study of Angiotensin Ⅱ type 1 receptor and endoplasmic reticulum stress in diabetic nephropathy
原文传递
导出
摘要 血管紧张素Ⅱ1型受体(AT1R)介导的免疫反应及相关内质网应激(ERS)反应所致肾脏细胞凋亡在DN进展中作用明显。阐述CKD进程中AT1R及相关ERS反应有助于在受体和分子水平完善其发病机制,有可能为延缓甚至逆转CKD进展、防止其转变为终末期肾病提供新的治疗靶点。 Recent advances shed light on the mechanisms of kidney cell apoptosis which is attributed to endoplasmic reticulum stress （ERS） and immune response mediated by angiotensin Ⅱ type 1 receptor （AT1R）.To enrich the cellular and molecular mechanisms of DN,the further study of AT1 R and its autoantibody,as well as the relative ERS response is very necessary.
作者 徐春艳 赵林双
机构地区 广州军区武汉总医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2014年第8期759-761,共3页 Chinese Journal of Diabetes
基金 湖北省自然科学基金(2011CHC001)
关键词 糖尿病肾病 血管紧张素Ⅱ1型受体 内质网应激 Diabetic nephropathy（DN） Angiotensin Ⅱ type 1 receptor （AT1 R） Endoplasmic reticulum stress （ERS）
分类号 R587.2 [医药卫生—内分泌] R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献2

二级参考文献12

  • 1Cheng D W, Jiang Y, Shalev A, et al. An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells [ J ]. Arch Physiol Biochem, 2006, 112(4-5). 189-218.
  • 2Kaneto H, Matsuoka T A, Nakatani Y, et al. Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes [J]. J Mol Med, 2005, 83(6) : 429-439.
  • 3King G L, Loeken M R, Hyperglycemia-induced oxidative stress in diabetic complications [ J ]. Histochem Cell Biol, 2004, 122(4): 333-338.
  • 4Rao R V, Peel A, Logvinova A, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the FaR chaperone GRP78[J]. FEBS Lett, 2002, 514(2-3): 122.- 128.
  • 5Schroder M, Kaufinan R J. The mammalian unfolded protein response[J]. Annu Rev Biochem, 2005, 74: 739-789,.
  • 6Ni M, Lee A S. ER chaperones in mammalian development and human diseases[J]. FEBS Lett, 2007, 581(19): 3641- 3651.
  • 7Ohse T, Inagi R, Tanaka T, et al. Albunin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells[J]. Kidney Int, 2006, 70(8): 1447-1455.
  • 8Hetz C, Russelakis-Carneiro M, Maundrell K, et al. Caspase-12 and endoplasmic reticulum stress mediate neurotoxieity of pathological prion protein[J]. EMBOJ, 2003, 22(20): 5435-5445.
  • 9曹延萍,李航,王建,刘青娟,段惠军.转录因子GADDl53/CHOP的激活与糖尿病大鼠肾组织固有细胞凋亡的关系初探[J].中国组织化学与细胞化学杂志,2010,19(5):453-456. 被引量：4
  • 10廖玉华,程龙献,涂源淑,张金枝,董继华,李淑莉,田元,彭又红.Mechanism of Anti-β-adrenoceptor Antibody Mediated Myocardial Damage in Dilated Cardiomyopathy[J].Journal of Huazhong University of Science and Technology(Medical Sciences),1997,17(1):5-8. 被引量：21

共引文献28

同被引文献45

  • 1Isidro ML. Sexual dysfunction in men with type 2 diabetes[J]. Postgrad MedJ, 2012, 88(1037): 152-159.
  • 2Schoeller EL, Schon S, Moley KH. The effects of type 1 diabetes on the hypothalamic, pituitary and testes axis[J]. Cell Tissue Res, 2012, 349(3): 839-847.
  • 3Jiang x, Zhang C, Xin Y, et al. Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress- dependent pathways in the mouse model[J]. Toxicol Lett, 2013, 219(1): 65-76.
  • 4Liu GL, Zhang YM, Dai DZ, et al. Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and I K B [3 and attenuated by argirein and valsartan[J]. Eur J Pharmacol, 2013, 713(1-3): 78-88.
  • 5Pulinilkunnil T, Kienesberger PC, Nagendran J, et al. Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy[J]. Diabetes, 2013, 62(5): 1464-1477.
  • 6Cox D J, Strudwick N, Ali AA, et al. Measuring signaling by the unfolded protein response [J]. Methods Enzymol, 2011, 491: 261-292.
  • 7Okada T, Yoshida H, Akazawa R, et al. Distinct roles of activating (ATF6) and double-stranded RNA-activated proteinkinase-like endoplasmic reticulum kinase (PERK) in transcription duringthe mammalian unfolded protein response[J]. Biochem J, 2002, 366(Pt 2): 585-594.
  • 8Richardson CE, Kinkel S, Kim DH. Physiologtical IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity[J]. PLoS Genet, 2011, 7(11): e1002391.
  • 9Kanter M, Aktas C, Erboga M. Curcumin attenuates testicular damage, apoptotic germ cell death, and oxidative stress in streptozotocin-induced diabetic rats[J]. Mol Nutr Food Res, 2013, 57(9): 1578-1585.
  • 10Koh PO. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes [J].J Vet Med Sci, 2007, 69(9): 969-971.

引证文献4

二级引证文献9

中国糖尿病杂志
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部