摘要
本文介绍了一种合成头孢曲松内酯的新方法,总摩尔收率96.4%,合成方法路线短、操作简便,收率高,产物结构经IR、MS、NMR等确证。此外,本文还对头孢曲松内酯进行了遗传毒性研究。
In this work, a novel method was introduced to synthesize eeftriaxone lactone with the mole yield of 96.4%. It was proved that this method is an effective route for the production with fewer steps, simpler operations and higher yields. The structure of the products is certified by IR, MS and NMR spectrums. In addition, the genotoxicity is also investigated for the ceftriaxone lactone.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2014年第8期590-593,614,共5页
Chinese Journal of Antibiotics
基金
"十一五"临床使用量大面广的药品杂质检测技术和安全控制指标研究(2008BA155B00)
四川省科技支撑计划:"功能化学品头孢地尼绿色合成工艺的实验和理论研究"(2012GZ0006)
关键词
合成
头孢曲松内酯
遗传毒性
Synthesis
Ceflriaxone lactone
Genotoxicity
