濮阳市2592例孕妇IgG抗-A(B)效价与新生儿溶血病的相关性

Correlation between IgG anti-A(B) titer and hemolytic disease of the newborn in 2592 pregnant women in Puyang city

目的：采用微柱凝胶技术检测孕妇血清IgG抗-A（B）血型抗体,为新生儿溶血病（HDN）的早期诊断和预防提供依据。方法：用微柱凝胶法检测在濮阳市妇幼保健院产科门诊建卡的孕妇IgG抗-A（B）效价,并追踪HDN的发生情况,分析二者的相关性。结果：2 592例受检O型血孕妇中,血清IgG抗-A（B）效价≤1∶128者1 433例,出生后可疑HDN 15例,HDN 5例,发生率为1.05%;血清IgG抗-A（B）效价为1∶256-1∶512者908例,HDN 27例,发生率为2.97%;血清IgG抗-A（B）效价≥1∶1 024者251例,HDN 41例,发生率为16.3%。孕妇IgG抗-A（B）不同效价组间HDN的发生率比较差异均有统计学意义（P〈0.05）。结论：随着孕妇血清IgG抗-A（B）效价的提高,HDN的发病率也增高。

Objective： To detect serum IgG anti - A （B） titer in pregnant women by microcolumn gel method, provide a basis for early diagnosis and prevention of hemolytic disease of the newborn （ HDN ） . Methods： Microcolumn gel method was used to detect IgG anti - A （B） titer in pregnant women from outpatient department of the hospital, the incidence rate of HDN was followed up, and the correlation was analyzed. Results： Among 2 592 pregnant women with type O blood, 1 433 pregnant women were found with serum IgG anti - A （B） titer≤ 1： 128, after delivery, 15 neonates were suspected of HDN and 5 neonates were diagnosed as HDN, the incidence rate was 1.05 % ; 908 pregnant women were found with serum IgG anti - A （B） titer 1 ： 256 - 1 ： 512, 27 neonates were diagnosed as HDN, the incidence rate was 2. 97% ; 251 pregnant women were found with serum IgG anti - A （B） titer≥1： 1 024, 41 neonates were diagnosed as HDN, the incidence rate was 16. 3%. There was statistically significant difference in HDN incidence rate among pregnant women with different IgG anti - A （B） titers （ P 〈 0. 05 ） . Conclusion： The incidence rate of HDN increases with the increase of serum IgG anti - A （B） titer in pregnant women.