丹参酮ⅡA磺酸钠对心肌梗死患者溶栓治疗后心肌氧化应激损伤的保护作用研究

Protective effect of sodium tanshinone ⅡA sulfonate on myocardial oxidative stress injury after thrombolytic therapy in acute myocardial infarction patients

目的研究丹参酮ⅡA磺酸钠对心肌梗死患者溶栓治疗后心肌氧化应激损伤的保护作用。方法将该院收治的160例急性心肌梗死患者随机分为观察组和对照组,各80例。观察组给予常规溶栓治疗和丹参酮ⅡA磺酸钠静脉滴注;对照组仅给予常规溶栓治疗。比较两组患者溶栓后心律失常发生情况以及检测治疗后不同时间点心肌酶谱和氧化应激指标。结果观察组患者室性期前收缩、室性心动过速和室性纤颤的发生率均低于对照组;治疗后2、4和6 h时,观察组患者的CK-MB、cTnT及MDA水平均低于对照组,GSH、SOD水平均高于对照组。结论丹参酮IIA磺酸钠能够减少心肌梗死患者溶栓心律失常的发生率和氧化应激所造成的心肌损伤,发挥对缺血再灌注心肌的保护作用。

[ Objective] To study the protective effect of sodium tanshinone II A sulfonate on myocardial oxidative stress injury of acute myocardial infarction patients after thrombolytic therapy. [ Methods ] 80 cases of acute myocar- dial infarction patients in our hospital were enrolled in observation group and received thrombolytic therapy and sodium tanshinone Ⅱ A sulfonate intravenous drip. The 80 patients in control group only received thrombolytic therapy. The incidence of arrhythmia, myocardial enzymes and oxidative stress index in different time point of two groups were detected and compared after thrombolytic therapy. [Results] Ventricular extrasystoles, ventricular tachycardia and ventricular fibrillation incidence of observation group was lower than that in control group. The CK- MB, cTnT and MDA levels of observation group in T1, T2, T3 time point after treatment were lower than those in control group. GSH, SOD levels were higher than those in control group.[ Conclusions] Sodium tanshinone Ⅱ A sulfonate exerted good protective effect on myocardial ischemia reperfusion injury by reducing the incidence of myocardial infarction and thrombolyticand oxidative stress.