罗库溴铵在不同七氟醚麻醉镇静水平下对BIS和Narcotrend值的影响

Rocuronium influnce on BIS and Narcotrend index in different Sevoflurane anesthesia sedation levels

目的在无手术刺激、不同七氟醚麻醉镇静水平下,观察非去极化肌松药罗库溴铵对BIS、Narcotrend的影响。方法选择30例ASAⅠ、Ⅱ级,年龄20-49岁,择期行全身麻醉下气管插管妇科手术的患者,按呼气末七氟醚的不同浓度随机分为A组（0.6 MAC）和B组（1.0 MAC）,每组15例。七氟醚吸入诱导,气管插管后调整七氟醚呼吸末吸入浓度为0.6 MAC与1.0 MAC,维持吸入15 min后,A、B两组静脉注射罗库溴铵（2ED90 0.6 mg/kg）观察20 min,连续监测两组BIS、Narcotrend值的变化。结果 A、B组注射罗库溴铵前后的BIS、Narcotrend值差异无统计学意义（P〉0.05）。结论七氟醚达到稳态吸入,呼吸末浓度在0.6MAC以上麻醉镇静水平时,静脉注射罗库溴铵不会对BIS、Narcotrend值产生影响。

[Objective] To observe the influence of non-depolarizing muscular relaxant Rocuronium on BIS and Narcotrend index in different Sevoflurane anesthesia sedation levels and without the operation stimulation. [Method] 30 ASA Ⅰ-Ⅱ patients, aged 20- 49, undergoing operation in gynecology department with tracheal intubation general anesthesia were randomly divided into two groups. The Sevoflurane end-expiration concentration was controlled in 0.6 MAC in group A,and 1.0 MAC in group B. After 15 minutes, all the pa- tients in both two groups were injected Rocuronium （2 ED90 0.6 mg/kg）. Then recorded the indexes of BID and Narcotrend on every patient for 20 minutes. [Result] After the injection,the differences of the BID and Narcotrend index between the two groups were not significant （P 〉0.05）. [Conclusion] The BIS and Narcotrend index would not be influenced by Rocuronium injection, when the Sevoflurane end-expiration concen- tration was controlled higher than 0.6 MAC.