基质金属蛋白酶-9在前列腺癌组织中的表达及其临床意义

Expression of matrix metalloproteinase-9 in prostate cancer tissue and its clinical significance

目的 探讨基质金属蛋白酶（MMP）-9在前列腺癌（PCa）组织中的表达及其临床意义.方法 采用免疫组织化学方法检测60例前列腺疾病患者组织中MMP-9的表达,60例患者中PCa 30例：Ⅰ期4例,Ⅱ期13例,Ⅲ期10例,Ⅳ期3例,良性前列腺增生（BPH） 30例.对PCa组织切片进行TNM分期,观察.结果 MMP-9在PCa组中阳性率为63.3％ （19/30）,BPH组为13.3％（4/30）,两者差异有统计学意义（P ＜0.05）;MMP-9阳性表达与PCa临床分期明显相关.转移组（Ⅲ＋Ⅳ期）MMP-9阳性率为76.9％（10/13）,非转移组（Ⅰ＋Ⅱ期）为52.9％（9/17）,两者差异有统计学意义（P＜0.01）.MMP-9阳性表达与肿瘤转移有相关.结论 MMP-9阳性表达提示患者预后差,可作为判断PCa浸润转移的指标.

Objective To investigate the expression of matrix metalloproteinase （MMP）-9 in prostate cancer tissue and its clinical significance.Methods Sixty patients with prostate diseases,including 30 cases of prostate cancer：stage Ⅰ in 4 cases,stage Ⅱ in 13 cases,stage Ⅲ in 10 cases and stage Ⅳ in 3 cases,and 30 cases of benign prostatic hyperplasia （BPH）.Thirty cases of PCa were observed based on the hematoxylin eosin staining for TNM staging.Results The positive rate of MMP-9 was 63.3％ （19/30） in prostate cancer group,and 13.3 ％ （4/30） in BPH group （P ＜ 0.05）.There was a close correlation between MMP-9 expression and clinical staging of prostate cancer.In the metastasis groups （stages Ⅲ and Ⅳ）,MMP-9 positive rate was 76.9％ （10/13）,and in the non-metastasis group （stages Ⅰ and Ⅱ） that was 52.9％ （9/17） （P ＜0.01）.There was a close correlation between MMP-9 expression and tumor metastasis.Conclusion MMP-9 positive expression was a hint of poor prognosis of prostate cancer patients,which can be used as an indicator of prostate cancer metastasis.