Kappa-肌动蛋白与细胞核增殖抗原在舌肿瘤组织中表达的相关性

Study on the correlation of Kappa-actin and proliferation cell nuclear antigen in tongue carcinoma

目的 探讨Kappa-肌动蛋白（Kappa-actin）与细胞核增殖抗原（Ki-67）在舌肿瘤组织中表达的相关性及其意义.方法 应用免疫组织化学法分别检测80例舌癌组织中Kappa-actin与Ki-67的表达,探讨其表达的相关性,分析Kappa-actin表达与临床病理特征的关系.结果 Kappa-actin及Ki-67在舌癌组织中的高表达率分别为62.5％、78.8％,两者表达呈正相关（P＜0.05）.同时,Kappa-actin表达与肿瘤的分化程度、分期及淋巴结转移密切相关（P＜0.05）,而与年龄、性别及肿瘤大小无相关（P＞0.05）.结论 Kappa-actin参与舌癌进展过程,其表达与Ki-67表达呈正相关.

Objective To investigate the significance and correlation of Kappa-actin expression and proliferation cell nuclear antigen （Ki-67） expression in tongue carcinoma.Methods Immunohistochemical method was used to detect the expression of Kappa-actin and Ki-67 in 80 cases of tongue carcinoma tissues,then the correlation between Kappa-actin and Ki-67 and relationship of Kappa-actin and clinicopathological characters were assessed.Results The rates of high Kappa-actin and Ki-67 expression were 62.5％,78.8％,respectively,with a significant correlation （P ＜0.05）.Meanwhile,Kappa-actin expression was associated with differentiation,stages and lymph node metastasis （P ＜ 0.05）,but not with age,gender and tumor size.Conclusion Kappa-actin is involved in the progress and significantly correlates with Ki-67 expression in tongue carcinoma.