期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

毕赤酵母过氧化物酶体吞噬的研究进展 被引量：2

The research progress of pexophagy in Pichia pastoris
原文传递
导出
摘要 过氧化物酶体吞噬是生物体的一种重要自我调控方式。过氧化物酶体吞噬是多种吞噬相关蛋白的共同作用,而且吞噬相关蛋白质之间的作用具有严格的时序性。由于毕赤酵母有两种吞噬方式、全基因组序列已知、基因操作技术成熟,所以毕赤酵母是研究过氧化物酶体吞噬的良好素材,也是目前研究的热点。本文对近年来毕赤酵母过氧化物酶体吞噬的启动、两种吞噬类型的形成、过氧化物酶体在液泡中降解的研究进行梳理,为毕赤酵母过氧化物酶体吞噬的进一步研究奠定基础。 Pexophagy is an important self-regulation mechanism. It is composed of various interactions by many autophagy related proteins （Atgs） according to strict spatial and temporal orders. Pichia pastoris was selected as the model to clarify the pexophagy mechanism for following reasons： two pexophagy modes, genome sequenced, and well-established gene manipulation protocols. In this review, the mechanism for Atgs involved in pexophagy activation, two pexophagy modes formation, and peroxisome degradation in vacuole of Pichia pastoris were organized, which provided a solid foundation for further research.
作者 张建国 黄勋娟 刘菲 刘俊秀
机构地区 上海理工大学医疗器械与食品学院
出处 《微生物学通报》 CAS CSCD 北大核心 2014年第8期1684-1691,共8页 Microbiology China
基金 国家自然科学基金项目(No.21306112) 上海市自然科学基金项目(No.13ZR1429100) 上海市高校青年教师培养计划资助
关键词 毕赤酵母 过氧化物酶体 自我吞噬 吞噬相关蛋白 Pichia pastoris, Peroxisome, Autophagy, Autophagy related protein
分类号 Q93 [生物学—微生物学]
  • 相关文献

参考文献1

二级参考文献73

  • 1Shintani T, Klionsky DJ. Cargo proteins facilitate the forma- tion of transport vesicles in the cytoplasm to vacuole target- ing pathway. J Biol Chem 2004; 279 (29): 29889-94.
  • 2Shintani T, Huang WP, Stromhaug PE, Klionsky DJ. Mecha- nism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell 2002; 3 (6): 825-37.
  • 3Yorimitsu T, Klionsky DJ. Atgl I links cargo to the vesicle- forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell 2005; 16 (4): 1593-605,.
  • 4Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 2007; 12 (2): 209-18.
  • 5He C, Song H, Yorimitsu T, Monastyrska I, Yen WL, Legakis JE, et al. Recruitment of Atg9 to the preautophagosomal struc- ture by Atgl I is essential for selective autophagy in budding yeast. J Cell Biol 2006; 175 (6): 925-35.
  • 6Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y. Atgl7 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells 2009; 14 (5): 525-38.
  • 7Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 1993; 260 (5104): 88-91.
  • 8Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autoph- agy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 2001; 152 (3): 519-30.
  • 9Stack JH, DeWald DB, Takegawa K, Emr SD. Vesicle-mediated protein transport: regulatory interactions between the Vpsl5 protein kinase and the Vps34 Ptdlns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol 1995; 129 (2): 321-34.
  • 10Slessareva JE, Routt SM, Temple B, Bankaitis VA, Dohlman HG. Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell 2006; 126 (1): 191-203.

共引文献13

同被引文献3

引证文献2

二级引证文献4

微生物学通报
2014年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部