不同临床表型支气管哮喘儿童T淋巴细胞亚群改变

T-leukomonocyte subgroups in children with various clinical phenotypes of bronchial asthma

目的探讨不同临床表型支气管哮喘儿童T淋巴细胞亚群改变情况,以期为儿童支气管哮喘的治疗提供理论依据。方法对23例婴儿短暂的喘息患儿、23例非特应性喘息患儿、41例特应性喘息/哮喘患儿外周血的T淋巴细胞亚群进行检测分析。结果特应性喘息/哮喘患儿CD4^+、CD4^+/CD8^+值高于婴儿短暂的喘息和非特应性喘息患儿,差异均有统计学意义(t值分别为2.843、2.873,均P<0.05);与FEV1/FVC和FEV1%呈明显的负相关(r值分别为-0.654、-0.676;-0.067、-0.675,均P<0.01),且与嗜酸性细胞计数和IgE呈正相关(r值分别为0.656、0.632;0.453、0.676,均P<0.01)。结论 T淋巴细胞亚群的改变可能是导致儿童发生特应性喘息/哮喘发病的因素,并且与特应性喘息/哮喘发病的严重程度密切相关。

Objective To explore the T-leukomonocyte subgroups in the children with various clinical phenotypes of bronchial asthma, so as to provide theoretical basis for treatment of children bronchial asthma. Methods Peripheral blood T-leukomonocyte subgroups were detected in 23 cases of infants with transient wheeze, 23 cases of nonatopic wheeze, and 41 cases of atopic wheeze/asthma, respectively. Results The contents of CD4 ＋ and CD4 ＋/CD8 ＋ were significantly higher in children with atopic wheeze/asthma than in those with transient wheeze and those with nonatopic wheeze, and the difference was statistically significant （ t value was 2. 843 and 2. 873, respectively, both P 〈0.05）. They were negatively correlated with FEV1 / FVC and FEVI% （r value was - 0. 654, - 0. 676, - 0. 067 and - 0. 675, respectively, all P 〈 0.01 ）. They were positively correlated with eosinophil count （ r value was 0. 656 and 0. 632, respectively, both P 〈 0.01 ） and IgE （ r value was 0. 453 and 0.676, respectively, both P 〈 0.01 ）. Conclusion T-leukomonocyte subgroup change may be the factor leading children atopic wheeze/asthma, and it is closely related with the severity of atopic wheeze/asthma.