降钙素原对小儿重症肺炎细菌病原体的鉴别

Identification of infant pulmonary bacterial infection pathogens with PCT

目的探讨小儿肺部不同细菌病原体感染时,人体降钙素原(PCT)、C-反应蛋白(CRP)的血清水平及白细胞(WBC)计数的变化。方法选取西安市儿童医院重症医学科肺部感染患者83例,分为革兰阴性菌组(49例)、革兰阳性菌组(34例)。入院后对患儿取晨起空腹静脉血5mL,行PCT、CRP测定,白细胞计数等检查。结果革兰阴性菌组PCT水平高于革兰阳性菌组,差异有统计学意义(t=8.44,P<0.05);两组患儿的CRP水平差异无统计学意义(t=1.61,P>0.05);两组患儿白细胞计数差异也无统计学意义(t=0.36,P>0.05)。结论降钙素原可用来区分肺部革兰阴性菌及革兰阳性菌感染,而CRP及白细胞计数特异性较低。

Objective To detect the value of procalcitonin （PCT） , C-reactive protein （CRP） and white blood cells （WBC） count in infant pulmonary bacterial infection with different pathogens. Methods A sample of 83 inpatients with pulmonary infection and hospitalized in pediatric intensive medicine of Xi＇ an Children＇ s Hospital were divided into gram-negative bacteria group （49 cases） and gram-positive bacteria group （34 cases）. After admission 5mL serum specimens were obtained to detect PCT, CRP and WBC count. Results The concentration of PCT in gram-negative bacteria group was significantly higher than gram-positive bacteria group （ t = 8.44, P 〈 0.05 ）. CRP and WBC count showed no significant difference between two groups （ t value was 1.61 and 0.36, respectively, both P 〉 0.05 ）. Conclusion PCT can be used to distinguish gram-negative bacterium infection from gram-positive bacterium infection in infant pneumonia, and the specificity of CRP and WBC is low.